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铝 镁 锌 锰等金属离子与钙调素相互作用研究进展 被引量：7

Recent advance of research on the interaction between trace element Al Mg Zn Mn and Calmodulin
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摘要 　金属离子由于配位环境与钙离子具有相似性,能够取代钙离子与钙调素产生竞争结合。对钙调素的结构、构象产生影响,进而对钙调素产生毒性作用。一些光谱及生物化学实验研究表明,Al3+、Mg2+、Zn2+、Mn2+及其它金属离子在与钙调素作用时,在作用力的强弱程度、结合位点、结合序及对钙调素的毒性作用具有各自的特殊性,本文概述了微量金属离子:K+、Na+、Mg2+、Zn2+、Al3+、Mn2+、Sr2+、Cu2+等与钙调素的相互作用及对钙调素生物功能产生的影响。 Microelement metal ion with ionic radii close to Ca2+can substitute for Ca2+to interact with Calmodulin ,and influence the configuration and biological activityon CalmodulIn. Many biological and chemical experiments show that Al3+?Mg2+?Zn2+?Mn2+and other metal ions interacting with Calmodulin have their own particularities in affinity, binding sites,binding order .The article sumrized the competitively binding of these ions to Calmodulin .
作者 肖凤娟 张欣杰
机构地区 石家庄铁道学院材料系 河北工业职业技术学院
出处 《河北省科学院学报》 CAS 2003年第3期163-167,共5页 Journal of The Hebei Academy of Sciences
关键词 铝 镁 锌 锰 金属离子 钙调素 相互作用 研究进展 竞争结合 毒性作用 结合位点 结合序 调节蛋白 Al^(3+) Mg^(2+) Zn^(2+) Mn^(2+) Calmodulin Competition binding Biological activity
分类号 Q510.3 [生物学—生物化学]
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参考文献23

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河北省科学院学报
2003年 第3期

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