微波法合成1H-1,2,3-三氮唑

Synthesis of 1H-1,2,3-Triazole under Microwave Irradiation

以苯并三氮唑为原料,以高锰酸钾为氧化剂,水为溶剂在105℃下氧化,以66 7%的收率制得1,2,3 三氮唑 4,5 二羧酸,然后微波脱羧制得1H 1,2,3 三氮唑,总收率达到64 7%。尤其在脱羧反应中,与常规方法相比,反应时间由6h缩短为6min,收率由65%提高到97%。总收率由43 4%提高至64 7%。产品用1HNMR、13CNMR、IR以及MS表征。

Starting with benzotriazole,1H1,2,3triazole was synthesized through two step reactions including oxidation by potassium permanganate and decarboxylation under microwave irradiation in overall yield of 647%.Compared with conventional method,in the decarboxylation reaction under microwave irradiation,the reaction time was reduced from 6 h to 6 min and the yield was enhanced from 65% to 97%.The product was corroborated by 1HNMR,13CNMR,IR and MS.