烯烃不对称双羟化反应中Tenta Gel树脂支载的可回收和重复使用的OsO_4催化剂研究(英文)

TentaGel-supported OsO_4 as Recoverable and Reusable Catalyst for Asymmetric Dihydroxylation of Olefins

合成了在烯烃不对称双羟化反应中可回收和重复使用的TentaGel支载的OsO4催化剂 .在DMF溶剂中 ,TentaGelHL Br与三乙胺反应生成季铵盐 ,在搅拌下后者与K2 OsO4饱和水溶液作用 2 4h ,过滤 ,得TentaGel OsO4催化剂 ,用去离子水在索氏提取器中连续提取 2 4h以除去吸附在TentaGel上未键合的K2 OsO4.TentaGel OsO4催化剂在反式 -二苯乙烯的不对称双羟化反应中化学产率≥ 80 % ,立体选择性≥ 93 %ee ,而且连续使用五次 ,其催化活性不变 .

Synthesis of a novel recoverable and reusable TentaGel-OsO4 catalyst is described. The resulting osmylated resin is air-stable and much easier to handle than its homogeneous counterpart (OsO4). Moreover, the resin-bound OsO4 exhibited excellent catalytic activity in the asymmetric dihydroxylation of olefins and was easily recovered and reused in five consecutive reactions, without significant decrease in activity.