蛋氨酸合成酶催化反应研究 VII.5-氨基-6-甲基尿嘧啶的合成研究

Study on the Catalytic Reaction of Methionine Synthase VII. Synthesis of 5-Amino-6-methyluracil

报道了 5 氨基 6 甲基尿嘧啶简便的合成方法 .该化合物以 6 甲基尿嘧啶 ( 2 )为起始物 ,经硝化或重氮化分别得到中间体 5 硝基 6 甲基尿嘧啶 ( 3 )和 5 偶氮苯基 6 甲基尿嘧啶 ( 4 ) ,化合物 3和 4经Na2 S2 O4还原 ,合成产物 5 氨基 6 甲基尿嘧啶 ( 1) .

Amino-6-methyluracil is a key intermediate compound of methionine synthase inhibitors, which can be synthesized from 6-methyuracil through two methods: (a) by reduction of 5-nitro-6-methyluracil and (b) by reduction of 5-phenylazo-6-methyluracil. Some modifications were made and a convenient procedure has been developed.