抗类风湿免疫调节剂对乙酰氨基苯乙酸的合成及其稳定性的初步研究

A study on the synthesis and stability of 4-acetylaminophe- nylacetic acid, an antirheumatic immunomodulator

以对硝基苯乙酸为原料,通过还原、酯化、酰化和水解反应合成对乙酰氨基苯乙酸(MS-932),并通过红外光谱、核磁共振谱和差示扫描量热法分析,确证其结构。对本品进行了稳定性的考察,实验表明本品在高温及光照条件下放置5和10d,其外观和含量无变化较稳定。

The title compound was prepared from 4-nitro-phenylacetic acid by reduction, esterification, acetylation and hydrolysis, and its structure was determined by IR, HNMR spectra and DSC. The stability of 4-acetylamino-phenylacetic acid was investigated and the result indicated that the appearance and content of 4-acetylaminophenylac-etic acid were stable at high temperature and under illumination for 5 and 10 days.