邻苯二甲酰亚胺在KF/Al_2O_3催化下的N-苄基化反应

N-Benzylation of phthalimide under the catalytic action of A1_2O_3 supported KF reagent

报道了无机载体试剂KF/Al2O3催化邻苯二甲酰亚胺的M苄基化反应,研究了反应体系中各因素对产率的影响。在DMF溶剂中,邻苯二甲酰亚胺和溴化苄的物质的量比为1:1.2,90℃反应6h,产率92.5％。

N-benzylation of phthalimide was carried out under the catalytic action of Al2O3 supported KF reagent. Various reaction factors affecting the yield have been studied. The optimal reaction conditions were,phthalimide and benzyl bromide molar ratio 1 :1. 2,reaction temperature 90℃ .reaction time 6h in DMF. The yield of N-benzy-lation of phthalimide was 92. 5%.