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血清中NSE水平在晚期NSCLC化疗中的临床意义 被引量：2

VALUE OF SERUM NEURON-SPECIFIC ENOLASE IN ADVANCED NON-SMALL CELL LUNG CANCER.
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摘要 目的 :探讨治疗前血清中神经特异性烯醇化酶 (NSE)水平对晚期非小细胞肺癌(NSCL C)近期化疗疗效及远期生存率的影响。方法 :用放射免疫法检测 14 5例 NSCL C治疗前血清中NSE水平 ,评价 3周期化疗后的疗效 ,随访生存率。结果 :NSE阳性组其近期化疗有效率高 (60 .1% ) ,疗效持续时间短 (2 .0个月 ) ,1年生存率低 (15.3 % ) ,NSE阴性组其近期化疗有效率低 (40 .7% ) ,疗效持续时间长 (5.9个月 ) ,1年生存率高 (40 .7% )。结论 :血清 NSE水平可作为预测晚期 NSCL Objective:To assess the prognostic value of pretre atment serum neuron-specific enolase(NSE) in advanced non-small cell lung canc er(NSCLC).Methods:Serum NSE levels were measured in 145 patients with previously untreated NSCLC. The effect after three periods chemotherapy we re evaluated, and the survival time followed-up.Results:The res ponse rate of chemotherapy was higher in NSE positive cases than in NSE negative cases. The survival time in NSE positive cases was shorter than in NSE negative cases.Conclusion:Serum NSE level in patients with advanced NSCL C maybe a efficient marker.
作者 阎飞 张定昌 朱爱琴
机构地区 上海市第八人民医院
出处 《肿瘤研究与临床》 CAS 2003年第5期323-324,共2页 Cancer Research and Clinic
关键词 非小细胞肺癌 神经特异性烯醇化酶 预后 NSCLC NSE Prognosis
分类号 R737.9 [医药卫生—肿瘤]
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参考文献6

  • 1欧阳能太,陈国勤,丁静,冉丕鑫,钟南山.非小细胞肺癌神经内分泌表达的检测及其临床意义[J].中华结核和呼吸杂志,2001,24(2):90-92. 被引量：13
  • 2Pujol J L, Boher J M, Grenier J. et al. Neuron-specific enolase(NSE) in the surveillance of small cell cancers. An evaluation of the prognostic information using Markov's model[J]. Rev Mal Res. 1998,15(4):519-525.
  • 3Hoster M, Kirchheiner T, Ruhle K H. et al. The "neuronspecific enolase" tumor marker as a prognoatic indicator in small cell bronchial carcinoma[J]. Pneumologie, 1995,49 (8) :470-474.
  • 4Skov B G. Sorensen J B, Hirsch F R, et a. Prognostic impact of histologic demonstration of chromogranin A and neuron specific enolase in pulmonary adenocarcinoma [J]. Ann Oncol,1991.2(5) : 355- 360.
  • 5Shibayama T,Ohnoshi T. Ueoka H ,et al. Serum neuron specific enolase(NSE) levels in patients with non small cell lung cancer[J]. Nihon Kyohu Shikkan Gakkai Zasshi, 1992, 30(6): 1097-1102.
  • 6Diez M, Torres A, Ortega L. et al. Value of serum neuron-specific enolase in nonsmall cell lung cancer[J]. Oncology,1993.50(2) :127-131.

二级参考文献1

共引文献12

同被引文献15

  • 1Iyoda A, Hiroshima K, Toyozaki T , et al . Clinical characterization of pulmonary large cell neuroendocrine carcinoma and large cell carcinoma with neuroendocrine morphology. Cancer, 2001,91 ( 11 ): 1992-2000.
  • 2Satoh H, Ishikawa H, Kurishima K, et al. Cut-off levels of NSE to differentiate SCLC from NSCLC. Oncol Rep, 2002,9(3) :581-583.
  • 3Keller T, Bitterlieh N, Hilfenhaus S,et al. Tumour markers in the diagnosis of bronchial carcinoma: new options using fuzzy logic-based tumour marker profiles. J Cancer Res Clin Oncol, 1998,124 (10):565-574.
  • 4Schneider J, Bitterlich N, Velcovsky HG, et al. Fuzzy logic-based tumor-marker profiles improved sensitivity in the diagnosis of lung cancer. Int J Clin Oncol, 2002,7 ( 3 ): 145-151.
  • 5Seemann MD, Beinert T,Furst H, et al. An evaluation of the tumour markers, carcinoembryonic antigen( CEA), cytokeratin marker( CYFRA21-1 )and neurou-specific enolase(NSE) in the differentiation of malignant from benign solitary pulmonary lesions. Lung Cancer,1999,26(3): 149-155.
  • 6Ferrigno D, Buecheri G, Giordano C. Neuron-specific enolase is an effective tumour marker in non-small cell lung cancer(NSCLC). Lung Cancer, 2003,41 ( 3 ) :311-320.
  • 7Santo A, Vattemi E. Can neuron specific enolase serum level predict chemotherapy response in patients with advanced non-small cell lung cancer. J Ann Oncol,2001,12( suppl 4) :63.
  • 8Pujol J, Boher J, Grenier J,et al. Cyfra 21-1 ,neuron specific enolase and prognosis of non-small cell lung cancer: prospective study in 621 patients. Lung Cancer,2001,31 (2-3) :221-231.
  • 9Jacot W, Quantin X, Boher JM , et al. Brain metastases at the time of presentation of non-small cell lung cancer:a multi-centric AERIO analysis of prognostic factors. Br J Cancer,2001,84 (7) :903-909.
  • 10黄宗华,徐丹丹,张飞艳,曾倩,李媛,宋丽华.血清ProGRP和NSE对评价小细胞肺癌化疗疗效及其预后的价值[J].中华肿瘤防治杂志,2015,22(22):1774-1778. 被引量：25

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肿瘤研究与临床
2003年 第5期

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