中医药干预PPARs及其通路治疗冠心病的研究进展

Research progress on intervention of traditional Chinese medicine on coronary heart disease through PPARs and related signaling pathways

过氧化物酶增殖物激活受体(PPARs)作为一类由配体激活的核转录因子超家族成员,属于Ⅱ型核受体超家族,控制细胞内多种代谢过程,具有广泛的生理和病理学功能。PPARs具有调节与脂代谢和葡萄糖代谢相关基因的功能,可直接下调促炎基因转录或间接影响脂代谢的转录效应来调控炎症反应。PPARs具有多效性,参与多种疾病的病理形成过程,例如肥胖、糖尿病、冠心病以及某些肿瘤疾病,因此是多种疾病的重要治疗靶点。文章就PPARs与冠心病的发生发展关系以及中药的干预作用作一概述。

Peroxisome proliferator-activated receptors(PPARs), a member of type II nuclear receptor superfamily, belong to the nuclear family of ligand activated transcriptional factors. PPARs affect the level of cell metabolism and undertake a variety of physiological and pathological role. The main function of PPARs is to regulate related genes of carbohydrate and fat metabolism. Moreover, PPARs are also known to regulate inlammatory processes through the directly or indirectly down-regulatory effect of transcription of proinflammatory genes or lipid metabolism. PPARs, which provide a key target for drugs, play an important role in the pathogenesis of many diseases, such as obesity, diabetes mellitus, coronary heart disease and some tumor, due to its pleiotropic effects. This paper reviews the relationship between PPARs and development of coronary heart disease, as well as the intervention of traditional Chinese medicine.