慢性阻塞性肺疾病稳定期疗效评价指标的权重分析

Weight analysis on evaluation index of curative effect of chronic obstructive pulmonary disease in stable stage

[目的]分析慢性阻塞性肺疾病(COPD)稳定期临床指标的权重特征,探讨科学、合理的疗效评价方法。[方法]利用70例COPD稳定期患者治疗前后的疗效评价指标数据作为样本,进行主成分分析并计算每个指标的权重;以治疗前权重为横轴,治疗后权重为纵轴,绘制象限图,分析各指标在治疗前后的重要性及变化趋势。[结果]1)圣乔治问卷、呼吸困难量表、临床症状积分出现在第一象限,治疗前后的权重均较高,未出现明显的权重游移;2)TNF-α位于接近象限图中心的位置,未出现权重的明显游移;3)六分钟步行试验、肺功能出现在第三象限,未出现权重的明显游移。4)BODE指数出现在第四象限,出现了权重的游移,治疗前权重较高而治疗后权重不高。[结论]采用权重分析结合象限图的方法对COPD稳定期临床指标进行评估和分析,可以初步明确各个指标在反映病情严重程度和对治疗敏感程度上的特性。

[Objective] To analyze the clinical indicators weight of COPD stable stage, and to explore the scientific and reasonable evaluation method. [Methods] Using the curative effect of evaluation data of 70 patients of COPD before and after treatment as sample,proceeding principal component analyse and calculate each index weight. Making the index weight before treatment for the horizontal axis and the index weight after treatment for the longitudinal axis, draw the quadrant diagram, analyze the importance of each index and the change trend. [Results] 1)St. George’s questionnaire, dyspnea scale, clinical symptoms appear in a quadrant, weight before and after treatment were higher, no significant weight wavering; 2)TNF-α was located near the Quadrant center position, and the weight did not appear obviously wandering; 3)Six minute walk test, pulmonary function appears in the third quadrant, no significant weight wavering; 4)BODE index appears in the fourth quadrant, the weight appeared wavering, and the weight of these indicators was high before treatment and low after. [Conclusion] By adopting the method of weighting analysis combined with the quadrant diagram of COPD stabilization clinical indicators for evaluation and analysis, the illness severity and treatment features sensitive degree can be reflected preliminarily and clearly.