摘要
目的 :评估肾病患者内源性肾小球滤过率 (GFR)。方法 :测定了 5 7例肾病患者和 39例健康对照血中CystatinC(CysC )、尿素、肌酐和肌酐清除率浓度。结果 :患者尿素、肌酐、肌酐清除率和CysC浓度与健康对照组间均存在明显差异 (P <0 .0 0 1 ) ;相关分析表明CysC和肌酐清除率之间 (P <0 .0 1 )、CysC和肌酐之间 (P <0 .0 1 )存在明显的相关关系。而肌酐和尿素之间 (P >0 .0 5 ) ,以及肌酐和肌酐清除率之间 (P >0 .0 5 )无明显相关关系存在。结论 :肾病患者血中CysC浓度增高 ,对GFR功能早期受损的评估优于尿素、肌酐和肌酐清除率。
Objective:To evaluate endogenous clearance marker glomerular filtration rate(GFR)in patients with renal diseases.Methods:The serum cystatin C,urea,creatinine,and creatinine clearance levels were determined in 57 patients with renal diseases and 39 healthy controls.Results:The levels of serum urea,creatinine,and creatinine clearance was found to be significantly higher in the patients with renal diseases than those in the healthy controls( P <0.001).The correlation was observed between cystatin Cand creatinine clearance levels( P <0.01),and between cystatin Cand creatinine levels( P <0.01).However,there were not correlation between creatinine and urea concentrations( P >0.05),and between creatinine and creatinine clearance levels( P >0.05).Conclusion:Serum cystatin C is probably more attractive for estimation of renal function than urea,creatinine,and creatinine clearance for detection of GFR in patients with early kidney diseases.
出处
《实用临床医学（江西）》
CAS
2003年第5期23-25,共3页
Practical Clinical Medicine
