不同类型冠心病患者血清C-反应蛋白与白细胞介素-6比较

Analysis of serum C-reactive protein and interleukin-6 in coronary heart disease

目的 :从临床角度结合冠状动脉造影结果分析不同类型冠心病 (CHD)患者血清C 反应蛋白 (CRP)和白细胞介素 6 (IL 6 )浓度差异 ,探讨炎症反应及冠状动脉狭窄程度在CHD发生发展中的作用以及两者的相互关系。方法 :检测 13例急性心肌梗死 (AMI)患者 (AMI组 )、4 0例不稳定型心绞痛患者 (UAP组 )、32例稳定型心绞痛患者 (SAP组 )以及 6 2例正常者 (对照组 )血清CRP、IL 6浓度 ,并结合冠状动脉狭窄程度分析不同类型CHD患者血清CRP和IL 6浓度差异 ,对血清CRP、IL 6及冠状动脉病变积分进行相关分析。结果 :CHD组患者血清CRP、IL 6显著高于对照组 [(5 .0 8± 2 .4 4 )∶(2 .32± 1.2 3)mg L、(15 .5 1± 3.5 4 )∶(11.5 6± 3.2 8)ng L],均P <0 .0 1。AMI组与UAP组间血清CRP、IL 6比较差异均无显著性意义 (P >0 .0 5 ) ,但均显著高于SAP组 (P <0 .0 5 ) ,SAP组血清CRP、IL 6均显著高于对照组 (P <0 .0 5 )。血清CRP与IL 6显著性相关 (r =0 .5 5 ,P <0 .0 1)。血清CRP、IL 6分别与冠状动脉病变积分显著性相关 ,相关系数分别为 0 .5 7和 0 .4 3,均 P <0 .0 1。结论 :不同类型CHD患者炎症反应水平不同 ,冠状动脉病变越广泛 ,血清CRP、IL 6水平增高越多 ,血清CRP、IL

Objective:To explore serum levels of C reactive protein (CRP) and interleukin 6 (IL 6) in coronary heart disease (CHD) as well as the severity of coronary lesions, and to estimate the correlation between serum CRP, IL 6 and CHD.Methods:The levels of serum CRP, IL 6 were detected respectively in 13 cases of acute myocardial infarction (AMI group), 40 of unstable angina (UA group), 32 of stable angina (SA group), and 62 age matched controls. The correlation between CRP, IL 6 and the severity of coronary lesions were assessed.Results:The mean levels of serum CRP, IL 6 were significantly higher in those with angiographically documented CHD than that in controls ( 5.08 ± 2.44 ) vs ( 2.32 ± 1.23 ) mg/L, P< 0.01 , ( 15.51 ± 3.54 ) vs ( 11.56 ± 3.28 ) pg/ml, P< 0.01 respectively. The serum levels of CRP, IL 6 were significantly higher in AMI group and UA group than those in SA group and controls (P< 0.05 ), but no difference between AMI group and UA group were found (P> 0.05 ). The serum level of CRP was significantly correlated with that of IL 6 (r= 0.55 , P< 0.01 ). Not only the levels of serum CRP but also IL 6 was significantly correlated with the extent of coronary disease (P< 0.05 ).Conclusion:Different extent of inflammation was demonstrated in different classification of CHD, and it was the most marked with AMI group and UA group. The serum levels of CRP, IL 6 increased with the extent of coronary disease. Serum CRP and IL 6 may play an important role in the pathogenesis of CHD.