通心络与硝酸甘油治疗心力衰竭临床分析

Clinical study on effects of tongxinluo and Nitroglycerin in patients with conge stive heart failure

目的 :研究通心络胶囊与硝酸甘油对慢性心力衰竭患者的临床疗效。方法 :将 112例心衰患者随机分为通心络组 (6 0例 )和常规组 (5 2例 ) ,常规组予硝酸甘油及常规综合治疗 ,通心络组在以上治疗基础上加用通心络胶囊 ,每日 3餐后口服 ,每次 3粒。在治疗前及治疗后 2wk分别行超声心动图、血液流变和临床检查 ,观察加用通心络后心功能和血流变的变化。结果 :通心络组总有效率高于常规组 ,心功能改善明显 ,两组血流变值均有显著降低。结论 :通心络胶囊可以改善心衰患者心功能和凝血功能 ,可以作为治疗该病的辅助药物。

AIM: To investigate the clinical effects of tongxinluo an d nitroglycerin in patients with congestive heart failure(CHF).METHODS: 112 CHF patients were assigned to the treatment group (60 cases) and the control group (52 cases) randomly.The patients in the control group were treat ed with nitroglycerin and routine general therapy, and those in the treatment gr oup were administrated with tongxinluo 3 capsules after each of three meals besi des nitroglycerin and routine general therapy. The echocardiography, hemorheolo gy and clinical examination were performed in patients with CHF prior and after 2-week treatment. The cardiac function and alternation of the hemorheology were observed after treatment. RESULTS: The total effective rate in the treatment group was higher than that in the control group. The cardiac func tion in the treatment group changed significantly,and the levels of plasma visc osity decreased in both groups significantly after treatment, especially in trea tment group. CONCLUSION: Tongxinluo can improve the cardiac fu nction and blood coagulation in patients with CHF.