氨氯地平联用依那普利治疗老年高血压病疗效评价

Clinical evaluation of amlodipine combined with enalapril in treatment of elderly patients with hypertension

目的 :观察氨氯地平与依那普利单用及联合应用治疗老年原发性高血压患者的临床疗效。方法 :10 0例老年高血压病患者随机分为 2组。 (1)氨氯地平组 (n =5 0 ) :口服氨氯地平 5mg ,每日 1次 ;(2 )依那普利组 (n =5 0 ) :口服依那普利 10mg ,每日1次。两组用药 2wk后 ,降压未达显效者 ,氨氯地平组联用依那普利 10mg ,每日 1次 ;依那普利组联用氨氯地平 5mg ,每日 1次 ,再观察 2wk。比较两组治疗前、后 2、4wk血压情况。结果 :氨氯地平组 2、4wk的降压总有效率分别为 6 2 %、94 % ;依那普利组 2、4wk的降压总有效率分别为 6 0 %、96 % ,两组组内比较P <0 .0 1,组间比较无统计学意义 (P >0 .0 5 )。两组均有轻度不良反应。结论 :氨氯地平或依那普利单用治疗老年原发性高血压有效 ,两药联用可提高降压效果。在单一用药基础上加药 ,药物时序不同对疗效影响不大。

AIM: To investigate the efficacy of amlodipine, enalapril, a nd amlodipine plus enalapril on elderly patients with hypertension. METHOD S: 100 cases were randomly assigned to two groups: 50 cases treated with 5 mg qd of amlodipine (amlodipine group), and another 50 cases treated with 10 mg qd enalapril of (enalapril group). After two weeks, the cases that blood pres sure was not decreased significantly were added enalapril 10 mg qd in amlodipine group and added amlodipine 5 mg qd in enalapril group for two weeks. RE SULTS: After two weeks and four weeks, the total effective rates were 62 % and 94% (P< 0.01 ) in amlodipine group, respectively, and we re 60% and 96% (P< 0.01 ) in enalapril group. No difference sh owed in the two groups. No severe side effects were found. CONCLUSIONS: Amlodipine, enalapril, and amlodipine plus enalapril can effectively dec reased blood pressure in the elderly patients with hypertension.