3Jing N, Marchand C, Liu J, et al. Mechanism of inhibition of HIV-1 integrase by G-tetrad-forming oligonucleotides in vitro [J]. J Biol Chem, 2000, 275(28):21460-21467.
4Gottfredsson M, Bohjanen PR. Human immunodeficiency virus type Ⅰ as a target for gene therapy[J]. Front Biosci,1997, 2:619- 634.
5d'Angelo J, Mouscadet JF, Desmaele D, et al. HIV-1 integrase: the next target for AIDS therapy[J]? Pathol Biol (Paris), 2001, 49(3) :237 - 246.
6Patrick H, Jonathan L. Retroviral DNA integration [J].Microbiol Mol Biol Rev,1999,63(4):836-843.
7Joseph PG. Retroviral integrase: conserved sequence information as a guide to understanding structure and function of the retroviral and bacterial IS3 DD(35) E transposases [J]. J Mol Struct (Theochem), 1998, 423(1/2) :41 -57.
8Bujacz G, Jaskolski M, Alexandratos J, et al. High-resolution structure of the catalytic domain of avian sarcoma virus integrase[J]. J Mol Biol, 1995, 253(2):333-346.
9Pommier Y, Marchand C, Neamati N. Retroviral integrase inhibitors year 2000: update and perspectives[J]. Antiviral Res, 2000, 47(3): 139 - 148.
10Neamati N, Sunder S, Pommier Y. Design and discovery of HIV-1 integrase inhibitors[J]. Ther Focus, 1997, 2(11):486 - 498.
1Dasgupta TK,Pezzuto JM. Use of betulinic acid and its derivatives for inhibiting malignant melanoma growth and a method of monitoring this[ P]. W, 96/29068.1996 - 09-26.
2Chang SY, Chang SY, Nohara T. Two new lupane-triterpene glycosides from leaves of Acanthoparax Koreanum [ J ] . Chem Pharm Bull, 1998,46 ( 1 ): 163 - 165.
4Srivastava AK, Shakeel M, Khan AA. QSAR studies on anti HIV-1 N-subtituted betulinic acid amides[ J ]. Ind J Chem, 2002,41B(2) :436 - 439.
5Sun IC, Chen CH, Kashiwada Y, et al. Anti-AIDS agents 49. synthesis, anti-HIV, and anti-fusion activities of IC9564 ana logues based on betulinic acid[ J ]. J Med Chem, 2002,45 ( 19 ):4271 - 4275.
6Fujioka T,Kashiwada Y, Kilkuskic RE, et al. Anti-AIDS agents 11,betulinic acid and platonic acid as anti-HIV principles from syzigium claviflorum and the anti-HIV activity of structurally related triterpenoids [ J ]. J Nat Prod, 1994,57 (2): 243 - 247.
7Pisha E, Chai H, Lee IS, et al. Discovery of betulinic acid as a selective inhibitor of human melanoma that function by induction of apoptosis[J]. Nat Med, 1995,1 (10): 1046 - 1051.
8Pezuto JM,Kosmeder JWH,Xu ZQ, et al. Prodrugs of betulinicacid derivatives for the treatment of cancer and HIV[P]. W,02/ 16395. 2001 - 08 - 18.
9Evers M, Poujade C, Soler F, et al. Betulinic acid derivatives: a new class of human immunodeficiency virus type 1 specific in hibitors with a new mode of action[J ]. J Med Chem, 1996,39(5):1056-1068.
10Sun IC, Wang HK, Kashiwada Y, et al. Anti-AIDS agents 34, synthesis and structure-activity relationships of betulin derivatives as anti-HIV agents [J]. J Med Chem , 1998,41 ( 23 ): 4648 -4657.