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春季角结膜炎的研究进展 被引量：15

Recent advances on vernal keratoconjunctivitis
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摘要 春季角结膜炎是儿童和青少年常见的慢性变态反应性眼表疾病 ,发病机理复杂 ,涉及IgE介导的免疫机制 ,也有体液和细胞介导的免疫机制。本文对春季角结膜炎的临床表现、病理生理变化和目前采用的治疗方法进行了介绍。 Vernal keratoconjunctivitis is a chronic allergic ocular surface disease existed primarily in children and youngsters. The precise pathogenic mechanism is complex including IgE mediated, cell mediated and humoral mediated immune process. In this article, we review the clinical manifestation, pathophysiology and treatment of vernal keratoconjunctivitis.
作者 费文雷
机构地区 中山大学中山眼科中心
出处 《眼科新进展》 CAS 2003年第5期377-379,共3页 Recent Advances in Ophthalmology
关键词 春季角结膜炎 病理生理学 vernal keratoconjunctivitis pathophysiology
分类号 R772.2 [医药卫生—眼科]
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参考文献35

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  • 2B~ney NP. Vernal and atopic keratoeonjunctivitis. In: Krachmer JH, eds. Cornea [M]. Vol Ⅱ. St Louis: Mosby-Year Book, 1997:811-813.
  • 3Anderson DF, MacLeod JD, Baddeley SM, Bacon AS, McGill JI,Holgate ST, et al. Seasonal allergic conjunctivitis is accompanied by increased mast cell numbers in the absence of leucocyte infiltration[J]. Clin Exp Allergy 1997, 27(9): 1060-1066.
  • 4Leonardi A,-RadieelVl, Fregona iA, Plebani M, Abatangelo G,Secchi AG. Histamine effects on conjunctival fibroblasts from patients with vernal conjunctivitis[J ]. Exp Eye Res 1999, 68 (6) : 739-746.
  • 5Leonardi A, Borghesan F, Avarello A, Plebani M, Seechi AG.Effect of lodoxamide and disodium cromoglycate on tear eosinophil cationic protein in vernal keratoconjunctivitis [ J ]. Br J Ophthalmol1997, 81(1): 23-26.
  • 6Abu-EI-Asrar AM. Fatani RA, Missotten L, Gehoes K. Expression of CD23/CD21 and CD40/CD40 ligand in vernal keratoconjunctivitis[J]. Eye 2001, 15 (P2): 217-224.
  • 7Abu-EI-Asrar AM, A1-Kharashi SA, A1-Mansouri S, Missotten L,Geboes K. Langerhans' cells in vernal keratoconjunctivitis express the costimulatory molecule B7-2 (CD86), but not B7-1 (CD80) [ J ]. Eye 2001, 15 (P5): 648-654.
  • 8Leonardi A, DeFranchis G, Zancanaro F, Crivellari G, DePaoli M,Plebani M, et al. Identification of local Th2 and Th0 lymphocytes in vernal conjunctivitis by cytokine flow cytometry [ J ]. Invest Ophthalmol Vis Sci 1999, 40(12): 3036-3040.
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眼科新进展
2003年 第5期

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