静滴国产奥美拉唑对消化性溃疡并出血的疗效及对胃内pH值的影响

Effect of Continuous Infusion of Chinese Omeprazole on Peptic Ulcer Bleeding and Intragastric Acidity

目的 观察国产奥美拉唑针剂对出血性消化性溃疡病人的止血和抑酸效果。方法 42例十二指肠溃疡并出血病人连续 3d静滴奥美拉唑 ,观察其止血时间。对其中 12例进行 2 4h胃内pH监测。同时回顾性比较了 5 0例用法莫替丁治疗溃疡出血的效果。结果 奥美拉唑组 37例 (88.1%)用药后 48h内止血 ,41例 (97.6 %) 72h内止血 ,明显优于法莫替丁组 (分别为 5 0 %和 76 %)。用药期间 2 4h胃内 pH≥ 6 .0水平的时间平均为 19.3h(占全天时间的 80 .2 4%)。结论 国产奥美拉唑针剂治疗出血性消化性溃疡疗效肯定 ,制酸快而作用强 ,能达到止血的 pH值要求。

Objective To observe the effectiveness of Chinese omeprazole injection in hemostasis and acid-inhibition on patients with ulcer bleeding.Methods 42 patients with duodenal ulcer bleeding were treated by continuous intravenous infusion of Chinese omeprazole for 3 days. The time of bleeding stop was observed and compared with 50 patients who were treated by famotidine. In 12 patients treated by Chinese omeprazole, the intragastric pH was monitored.Results In 37 of 42 patients(88.1%)in 48 hours and 41 patients(97.6%)in 72 hours, bleeding stopped after being treated by Chinese omeprazole. And the time above intragastric pH 6 was 19.3 hours(80.24% of 24 hours).Conclusion Chinese omeprazole is very effective on peptic ulcer bleeding and it can effectively control intragastric pH of such patients.