小剂量甲状腺素治疗慢性心力衰竭疗效观察

ON THE CLINICAL EFFICACY OF LOW DOSE THYROXINE IN CHRONIC HEART FAILURE

目的 :观察小剂量甲状腺素治疗慢性心力衰竭的疗效。方法 :随机分组 ,观察组 32例 ,对照组 31例。观察组在常规抗心衰治疗的基础上加用甲状腺素 2 0 mg/d。疗程 4个月。结果 :观察组与对照组在研究结束时的左室射血分数 ( LVEF)及左室舒张功能指标 E峰 /A峰 ( E/A)明显改善 ( P<0 .0 5 ) ,但观察组上述指标改善更明显 ( P<0 .0 5 )。结论 :小剂量甲状腺素使心功能明显改善 ,LVEF及 E/A增加 ,治疗慢性心力衰竭疗效良好。

Objective:To evaluate the effect of low dose thyroxine on chronic heart failure.Methods:63 patients were randomly divided into two groups,,treatment group (32 patients) and control group (31 patients).The treatment group used low dose thyroxine in addition to standard therapy. Results:LV ejection fraction (LVEF) and the standard of diastole (E/A) improved significantly in two groups at the end of the study.The treatment group improved much more . Conclusion:This study demonstrates that low dose thyroxine can improve cardiac function and increase LVEF and E/A,and has a good efficacy in chronic heart failure.