口服罗红霉素治疗不稳定型心绞痛疗效观察

ANTIMICROBIAL TREATMENT OF ROXITHROMYCIN FOR UNSTABLE ANGINA

目的 :探讨罗红霉素对不稳定型心绞痛 ( UAP)的疗效及其对 UAP短期预后的影响。方法 :选择住院 UAP病人 1 63例 ,所有病人接受强化药物治疗 ,随机分到罗红霉素组的病人自入院当天起给予罗红霉素 1 5 0 mg,每日 3次 ,疗程为 30 d。结果 :治疗 30 d后 CRP、FG水平在罗红霉素组明显下降 ( P<0 .0 5 ) ,90 d时下降更明显 ( P<0 .0 1 ) ;UAP罗红霉素治疗组的疗效优于常规治疗组 ,罗红霉素治疗组良好控制率87.6% ,常规治疗组 75 .6% ,两组比较有显著性差异 ( P<0 .0 5 )。罗红霉素组 3个月内 AMI、死亡、被迫介入治疗、UAP复发率均较常规治疗组明显降低 ( P<0 .0 5 )。结论 :罗红霉素抗炎治疗明显降低炎性标志物水平 ,同时也明显改善

Objective:To evaluate the effect of antimicrobial treatment with roxithromycin on unstable angina.Methods:163 patients with unstable angina were randomly assigned to receive roxithromycin(150 mg,tid)treatment or not for 30 days.Results:C reactive protein and fibrinogen levels were reduced( P <0 05)in unstable angina patients receiving roxithromycin.This reduction persisted during 90 days follow up ( P <0 01).The death,myocardial infarction,compeled intervention treatment or recurrent unstable angina decreased in treatment group( P <0 05)compared with those in routine treatment group.Conclusion:Antibiotic treatment significantly reduced the level of inflammation serum markers and improved the short term prognosis in patients with unstable angina.