摘要
目的 :探讨感染病原体总负荷、血清C 反应蛋白 (CRP)与冠心病的关系。 方法 :冠心病组 10 2例 ,对照组 62例 ,检测血清抗肺炎衣原体、抗巨细胞病毒、抗腺病毒、抗单纯疱疹病毒 1型、抗幽门螺旋杆菌 5种IgG型抗体以及CRP水平。根据抗体阳性数分为少于或等于 (≤ ) 2个抗体阳性患者、 3~ 4个抗体阳性患者、 5个抗体阳性患者 ,分析抗体阳性率与冠心病的关系、感染病原体总负荷、CRP水平与冠心病的关系。 结果 :抗肺炎衣原体、抗巨细胞病毒、抗腺病毒、抗单纯疱疹病毒 1型、抗幽门螺旋杆菌等 5种IgG型抗体的阳性率分别是 79 88% (13 1/164 )、 71 95 % (118/164 )、 66 46% (10 9/164 )、 83 5 4% (13 7/164 )、 43 90 % (72 /164 )。接近 80 %的患者有 3种或 3种以上抗体阳性。用危险因素调整后的以上 5种病原体对冠心病危险作用大小的危险比及其 95 %可信限分别是 4 4(1 8~ 10 6)、 11 9(5 0~ 2 8 6)、 2 7(1 3~ 5 5 )、 5 5 (2 0~ 14 7)、 0 1(0 0 4~ 0 2 3 ) ,相互间均有显著性差异 (P <0 0 1)。≤ 2个抗体阳性患者、 3~ 4个抗体阳性患者、 5个抗体阳性患者其冠心病百分率分别是 2 5 0、60 7、 10 0 0 (P <0 0 5 )。 3~ 4个抗体阳性患者与≤ 2个抗体阳性患者比较 ,血?
Objective: To investigate the effects of total pathogen burden on coronary heart disease(CHD)risk and the serum levels of C reactive protein(CRP) Methods: In 164 individuals,including 102 CHD patients and 62 controls,IgG antibodies to chlamydia pneumoniae,cytomegalovirus,adenovirus,herpes simplex virus type 1 and helicobacter pylori,and the serum levels of CRP were measured Analyses of effects of total pathogen burden on CHD risk and the serum levels of CRP were performed Results: The prevalence of IgG antibodies to the pathogens in the 164 patients were as follows: 131 for chlamydia pneumoniae(79 88%),118 for cytomegalovirus(71 95%),109 for adenovirus(66 46%),137 for herpes simplex virus type 1(83 54%)and 72 for helicobacter pylori(43 90%).About 80% of the subjects were exposed to more than 3 of the 5 pathogens tested.Association of the prevalence of CHD with seropositivities with chlamydia pneumoniae,cytomegalovirus,adenovirus,herpes simplex virus type 1 and helicobacter pylori were significant after multivariate analysis and adjustment for traditional CHD risk factors.The OR and 95% CI were 4 4(1 8 10 6),11 9(5 0 28 6),2 7(1 3 5 5),5 5(2 0 14 7) and 0 1(0 04 0 23),respectively.And the percentages of CHD for groups with pathogen burden≤2,3 or 4,and 5 were 25 0,60 7,and 100 0, respectively.The seropositivities were associated with an increased prevalence of CHD(p<0 05).The serum levels of CRP were (2 32±1 23) mg/L,(4 71±2 48) mg/L,(5 62±2 93) mg/L in patients exposed to≤2,3 4 and 5 pathogens,respectively(p<0 05) Conclusion: Increased pathogen burden is associated with elevated serum levels of CRP.The greater the pathogen burden,the more significant the inflammatory reaction,and so the higher risk the CHD is
出处
《中国循环杂志》
CSCD
北大核心
2003年第4期249-252,共4页
Chinese Circulation Journal