摘要
目的 :观察中草药益母草对雄性小鼠生殖细胞的遗传毒性。方法 :采用小鼠精子畸形试验、精原细胞姐妹染色单体互换试验和小鼠精子非程序 DNA合成试验。结果 :益母草各剂量组所诱导的小鼠精子畸形频率和精原细胞姐妹染色单体互换频率与正常对照组比较 ,差异无显著性( P>0 .0 5 ) ,益母草不能诱导小鼠精子非程序 DNA合成。结论 :益母草对雄性小鼠生殖细胞无遗传毒性。
Objective:To examine the genetic toxic effect of Herba leonuri on male mouse reproductive cells. Methods:Sperm abnormality test, sister chromatid exchange(SCE) test in mouse spermatogonia and unscheduled DNA synthesis(UDS) test in mouse sperms were used. Results:Sperm abnormality or SCE was no significant difference between tested groups and control group ( P <0.05),indicating that Herba leonuri could not induce any UDS in mouse sperms.Conclusion:Herba leonuri has no genetic toxicity in male mouse reproductive cells. [
出处
《吉林大学学报（医学版）》
CAS
CSCD
北大核心
2003年第5期560-562,共3页
Journal of Jilin University：Medicine Edition
基金
吉林省科技发展计划项目 (2 0 0 10 5 2 9)
