淡豆豉对去卵巢大鼠脂代谢的影响

Effects of Semen Sojae Preparatum on Lipid Metabolism in Ovariectomized Rat

目的 探讨淡豆豉抗动脉硬化机制。方法 :采用大鼠去卵巢的方法建立脂代谢紊乱模型 ,观察血脂、脂蛋白、脂质过氧化物的变化。结果 :淡豆豉治疗 12周后 ,甘油三酯 (TG)、氧化低密度脂蛋白 (OX LDL)和丙二醛(MDA)明显较去卵巢组降低 (P <0 0 5或P <0 0 1) ,高密度脂蛋白 (HDL c)、载脂蛋白 (apo AI)和超氧化物歧化酶(SOD)活力明显较去卵巢组升高 (P <0 0 5或P <0 0 1)。结论 :淡豆豉抗动脉硬化机制与其调节血脂、抗氧化有关。

Objective:To investigate the antiatherosclerotic effect of Semen Sojae Preparatum(SSP) and its mechanism.Methods: 48 rats were randomly divided into sham operation group (sham),ovariectomized group (OVX)and three doses of OVX+SSP groups.SSP was given to OVX+SSP groups 2 weeks after ovariectomy.The levels of serum lipids and lipid peroxidation were detected after 12 weeks treatment.Results:SSP lowered serum oxidized-low density lipoprotein cholesterol (OX-LDL,P<0.01),triglyceride (TG,P<0.01) and malondialdehyde (MDA,P<0.05 or P<0.01), and enhanced serum high density lipoprotein cholesterol (HDL-c,P<0.05 or P<0.01),polipoprotein A I (apo-AI,P<0.01) and superoxide dismutase (SOD,P<0.01) activity.Conclusion:SSP had effects on regulating lipid and antioxidation. Therefore, it might inhibit atherosclerosis in ovariectomy rats.