脑血管病病人血浆溶血磷脂酸水平的临床意义

Clinical Significance of the Content of Lysophosphatidic Acid in Plasma of Cerebrovascular Patient

目的 :探讨溶血磷脂酸 (LPA)水平与脑血管病的关系。方法 :采用LPA新型检测方法。结果 :短暂性脑缺血 (TIA )组LPA水平最高 3 .5 7μmol/L±2 .70 μmol/L ,脑梗死组次之 2 .69μmol/L±0 .65 μmol/L。经抗血小板治疗 ,临床症状和体征改善后 ,LPA水平逐渐恢复正常。结论 :LPA是发生脑卒中或冠心病的前兆 ,可作为预警因子。

Objective:To explore the relationship between lysophosphatidic acid (LPA) content and cerebrovascular disease.Methods:A new detective item of LPA was adopted.Results:The content of LPA (3.57±2.70) for transient ischemia attack (TIA) was the highest,while the content of LPA (2.69±0.65) for cerebral infarction was followed by. The content of LPA could recovery gradually to normal value with the improvement of clinical symptoms and physical sign treated with anti-platelet. Conclusion:LPA was warning of causing cerebral apoplexy or coronary heart disease, that was pre-warning factor, which indicated the platelet has activated, and it would be the key action for the formation of atherosclerosis(P<0.001).LPA detection should be placed on routine examination item.