不稳定型心绞痛发作的时辰节律性分析

Circadian Variation in Pain Onset in Unstable Angina Pectoris

目的 :探讨不稳定型心绞痛 (UAP)发作的时辰节律性。方法 :选取 3 12例UAP病人 ,按照胸痛发作的时间分为 4个时间段 ,分别为 0 0 :0 0～ 0 6:0 0、0 7:0 0～ 12 :0 0、13 :0 0～ 18:0 0和19 :0 0～ 2 4:0 0。结果 :UAP胸痛发作高峰期时间段为 0 7:0 0～12 :0 0 ,根据性别、年龄和既往病史亚组分析也有相同的发作时间分布规律。结论 :UAP发作具有明显的时辰节律性。

Objective:To investigate the circadian distribution of pain onset in patients with unstable angina pectoris (UAP).Methods:312 patients with UAP were grouped according to the time of onset of symptoms in 6-hour intervals, viz.00:00～06:00,07:00～12:00,13:00～18:00 and 19:00～24:00.Results:The peak incidence of pain onset occurred between 6A.M. and noon (P<0.001), the circadian distribution of pain onset was analyzed also by gender, age groups and previous medical history.Conclusions:This study clearly demonstrates a statistically significant variation in the circadian distribution of pain onset in UAP.