清瘟败毒饮治疗蛇伤致弥漫性血管内凝血临床观察

Clinical Observation on Treatment of Snake Bite Induced Disseminated Intravascular Coagulation by Qinwen Baidu Decoction

目的 :观察清瘟败毒饮在治疗蛇伤致弥漫性血管内凝血 (DIC)中的作用。方法 :选择 4 6例蛇伤致DIC患者按单盲随机法分为两组。对照组 (使用抗蛇毒血清、补充凝血因子等西医常规治疗 ) 16例 ,与治疗组 (在对照组的基础上加用清瘟败毒饮治疗 ) 30例作比较 ,观察其疗效及DIC主要的客观指标 (血小板、纤维蛋白原及凝血酶原时间 )的恢复时间。结果 :治疗组的总有效率 (93 33% )和DIC主要的客观指标的恢复时间 ,分别与对照组比较 ,差异均有显著性 (P <0 0 1)。结论 :清瘟败毒饮在治疗蛇伤致DIC中有明显缩短疗程 ,提高疗效的作用。

Objective:To observe the effect of Qinwen Baidu Decoction (QBD) in treating snake bite induced dissseminated intravascular coagulation (DIC). Methods:Forty-six patients were randomly divided into the control group (n=16) and the treated group (n=30). They were all treated with the conventional therapy, including application of anti-snake venom serum and supplement of blood agglutination factors. For the treated group, QBD was administered additionally. The efficacy of treatment, chief indexes for DIC (platelet, fibrinogen and prothrombin time) and their recovery time, etc. were observed. Results:The total effective rate of the treated group was 93.33%, which was higher than that of the control group (56.35%), and the recovery time of chief DIC indexes in the treated group was significantly shorter than that in the control group respectively (P<0 01). Conclusion:QBD shows obvious effects of shortening therapeutic course and enhancing efficacy in treating snake bite induced DIC.