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缬沙坦对慢性肾衰竭高血压患者血浆内皮素的影响及临床意义 被引量:1

The Effect of Valsartan on the Plasma Endothelin of Patients With Chronic Renal Failure Complicating Hypertension Patients and Its Clinical Significance
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摘要 目的 :观察缬沙坦对慢性肾衰竭 (CRF)合并高血压患者血浆内皮素 (ET)、降钙素基因相关肽 (CGRP)含量、尿蛋白和Q -T离散度 (Q -Td)的影响。方法 :将慢性肾衰竭患者分为血压升高组 (研究组 )24人 ,口服缬沙坦80mg/d ,共治疗4wk ;血压正常组 (对照组 )20人 ,健康对照组9人 ,分别测定研究组用药前、后与对照组及健康组的血浆ET和CGRP含量、24h尿蛋白定量及Q -Td。结果 :(1)CRF患者血浆ET含量均高于健康组 ,且CRF研究组高于CRF对照组 ,药物治疗后ET含量下降 ;(2)CRF患者血浆CGRP含量高于健康组 ,且CRF研究组高于CRF对照组 ,药物治疗后CGRP含量明显升高 ;(3)CRF患者尿蛋白高于健康组 ,且CRF研究组高于对照组 ,药物治疗后尿蛋白减少 ;(4)CRF患者合并高血压后Q -Td明显比对照组及健康组延长 ,药物治疗后无明显改变。结论 :缬沙坦可治疗CRF合并高血压患者 ,有效降血压、降尿蛋白 ,延缓肾功能恶化 。 OBJECTIVE:To observe the influence of Valsartan on the serum ET?CGRP levels?urinary protein and Q-Td of patients with CRF complicating hypertension.METHODS:CRF research group including 24 patients with CRF complicating hypertension receiving Valsartan 80mg/d for 4 weeks;CRF control groups including 20 CRF patients with normal blood pressure;health group including 9 health people.The serum ET and CGRP levels?urinary protein?and Q-Td were measured.RESULTS:(1)The serum ET level of CRF patients was higher than that of health people;The serum ET level of CRF research group(before treatment) was higher than that of CRF control group and decreased after treatment of Valsartan.(2)The serum CGRP level of CRF patients was higher than that of health people.The serum of CGRP level of CRF research group(before treatment) was higher than that of CRF control group and continued to increase after treatment of Valsartan.(3)The content of urinary protein of CRF patients was significantly higher than that of health people.The content of urinary protien of CRF research group before treatment was higher than that of CRF control group and decreased after treatment of Valsartan.(4)The Q-Td of CRF research group was longer than that of health group and CRF control group.But the Q-Td of CRF research group did not change after treatment of Valsartan.CONCLUSION:Valsartan could effectively control blood pressure and decrease content of urinary protein,and delay the deterioration of renal function,but could not reverse the cardiovascular remoulding.
作者 杜娟 徐学明
出处 《中国医院用药评价与分析》 2002年第4期220-222,共3页 Evaluation and Analysis of Drug-use in Hospitals of China
关键词 缬沙坦 慢性肾衰竭 高血压 血浆内皮素 合并症 endothelin calcitonin gene-related peptide proteinuria Q-T intervcal dispersion hypertension Valsartan chronic renal failure
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  • 1The United States Renal Data System.Excerpts from the USRDS 1997 annal data report[J].Am J Kidney Dis, 1997, 30(suppl 1): 40.
  • 2JV Lachojannis.The secret of endothelin- 1 increasing in renal failure patient[J].Nephrol Dial Transplant, 1997, 12: 470.
  • 3Ujiie K, Terada Y, Nonoguchi H, et al.Messenger RNA expression and synthesis of endothelin- 1 along rat ne- phron segments[J].J Chin Invest, 1992, 90: 1 043.
  • 4邱强.内皮素受体拮抗剂与肾脏疾病[J].肾脏病与透析肾移植杂志,1998,7(1):70-72. 被引量:3
  • 5Fujioka S, Sasakawa V, kishimoto H, et al.The antihy- pertensive effect of calcitonin gene- related peptide in the rat with noreqine phrine and angiotension- Ⅱ indu- ced hypertension[J].J Hypertens, 1991, 9: 175.
  • 6Supowit SC, Ramcma CV, Westlund KN, et al.Calciton- in gene- related peptide gene expression in the sponta- neously hypertensive rat[J].Hypertens, 1993, 21: 1 010.
  • 7Xiao ZS, Li XY, Deng HW.Ischemic preconditioning medicated by calcitonin gene- related peptide in isolat- ed rat heart[J].Acta Pharmacol Sin, 1996, 17: 445.
  • 8董光富.蛋白尿和慢性肾功能衰竭进展关系研究近况[J].国外医学(泌尿系统分册),1998,18(4):165-168. 被引量:13
  • 9Schiffrin EL.Vascular remodeling and endothelial func- tion in hypertensive patients: Effects of antihypertensive therapy[J].Scand Cardiovas J, 1998, 47(suppl): 15.

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