我国1979年～2001年241例抗真菌药的不良反应分析

Review of 241 Cases of Adverse Reactions Induced by Antifungals in China During the Period 1979～2001

目的 :探讨抗真菌药不良反应的发生规律 ,以指导临床合理用药。方法 :对1979年～2001年国内文献报道的241例抗真菌药的ADRs进行分析。结果 :241例ADRs中 ,皮肤科外用制剂所致ADRs为39例 ,口服及注射制剂所致ADRs202例 ;涉及11种抗真菌药ADRs的临床类型主要有肝损害69例 ,过敏反应48例 ,血液系统反应26例 ,内分泌紊乱16例 ,神经系统反应15例 ,消化系统反应9例 ,心血管系统反应7例 ,泌尿系统反应4例 ,呼吸系统反应1例 ,其他反应7例。结论 :应加强抗真菌药的监测 。

OBJECTIVE:To investigate the characteristics of ADRs induced by antifungals to guide rational drug use.METHODS:241 cases of ADRs induced by antifungals reported in demestic literatures,issued from 1979 to 2001,were collected and analyzed.RESULTS:Among the 241 cases,39 ADRs were induced by topical preparations,202 ADRs by oral or injecting preparations.The clinical manifestations of ADRs induced by 11 kinds of antifungals were as follows:liver damage(69),allergic reactions(48),hematologic reactions(26),endocrinologic reactions(16),nervous system reactions(5),digestive system reactions(9),cardiovascular system reactions(7),urinary system reactions(4),respiratory system reaction(1) and other reactions(7).CONCLUSION:The use of antifungals should be under strict monitoring to reduce the occurrence of serious ADRs.