摘要
目的探讨缺氧/复氧对肾动脉内皮依赖性一氧化氮(NO)和内皮衍性超极化因子(EDHF)途径舒张功能的影响。方法采用器官槽法,以兔肾动脉环为研究对象,首先抑制PGI2舒张途径,然后再分别抑制NO和EDHF舒张途径,对给与血管环以缺氧/复氧处理,观察缺氧/复氧分别对NO和EDHF舒张途径的影响。结果缺氧/复氧使NO途径的内皮依赖性舒张功能减退,而缺氧/复氧对EDHF途径的内皮依赖性舒张功能无变化。结论缺氧/复氧导致兔肾血管内皮衍性NO途径的舒张损伤,而对EDHF途径的舒张无影响。
Objective To investigate the effect of hypoxia-reoxygenation on of endothelium-dependent NO and endotheli-um-derived hyperpolarizing factor (EDHF) relaxation of. Methods The organ chamber technique was employed to study rab-bit renal artery rings. By inhibiting the PGI 2 relaxation pathway with hypoxia-reoxygenation of the renal artery rings, followed by inhibition of NO and EDHF relaxation pathways respectively, the effects of hypoxia-reoxygenation on NO and EDHF re-laxation were observed. Results Hypoxia-reoxygenation decreased the endothelial NO relaxation of rabbit renal rings, but the endothelial EDHF relaxation. Conclusion Hypoxia-reoxygenation may injure endothelium-derived NO relaxation, but not the endothelium-derived EDHF relaxation of rabbit renal rings.
出处
《第一军医大学学报》
CSCD
北大核心
2003年第9期925-928,共4页
Journal of First Military Medical University
