维思通与氯氮平对精神分裂症患者生活质量的影响

The effects of risperidone and clozapine to patients with schizophrenia's life quality.

目的 比较维思通和氯氮平对精神分裂症患者生活质量的影响。方法 将 6 2例符合CCMD - 3标准的精神分裂症患者随机分为两组 ,分别给予维思通和氯氮平治疗 ,并随访半年 ,观察两药对患者生活质量和精神症状的影响。并以PANSS评定精神症状 ,以生活质量量表 (WHO ,QOL - 10 0 )评估生活质量 ,以TESS评定药物副反应。结果 维思通和氯氮平对精神分裂症阳性症状和阴性症状的改善相近 ;对一般精神病理症状和PANSS总分的改善前者优于后者 ;维思通比氯氮平能更好地改善患者的生活质量。结论 维思通比氯氮平能更好地改善精神分裂症的生活质量 ,有利于患者恢复社会功能 。

Objective To compare the effect of schizophrenia's life quality using risperidone and clozapine.Methods 62 patients met the criteria of CCMD-3 for schizophrenia were randowly divided into groups.Risperidone and clozapine were given respectively,and had a follow up half year.Observed their effect to patient's life quality and psychiatric symptoms,PANSS were used to access psychiatric symptoms.WHO,QOL-100 were used to access life quality.TESS were used to evaluated side effect.Result There are similar result in improvement of positive symptoms and negative symptoms.But risperidone is superior in improvement of psychiatric symptoms and PANSS than clozapine.Risperidone have good result in improving the life quality.Conclusion Risperidone can improve the life quality of the schizophrenic patients better than clozapine.