持续闭式引流配合沙培林注入治疗癌性胸水的临床观察

Chinical study of continuous closed drain combined with streptococcal preparation(ok-432)in treatment of malignant pleural effusion.

目的 观察胸腔持续闭式引流配合沙培林注入 ,治疗癌性胸水的效果和毒副反应。方法 B超定位后行胸腔持续闭式引流 48～ 72小时至胸水尽 ,青霉素皮试阴性者 ,予沙培林 5KE +生理盐水 2 0ml注入胸腔。四周后复查评价疗效。结果 全组 48例 ,总有效率 95 .8%,基本达到一次性治愈。其中CR39例 (81.3%) ,PR7例 (14.6 %) ,SD2例 (4.2 %) ,无PD。主要毒副反应为发热、胸闷及恶心。结论 持续闭式引流配合沙培林注入是治疗癌性胸水的有效方法 ,毒副反应轻 ,值得临床推广。

Objective To evaluate the therapeutic effect and toxicities of closed drain combined with streptococcal preparation(ok-432)in treatment of malignant pleural effusion.Methods After Super-B wave examination on pleural effusion,the continuous closed drain would last 48～72 hours until the hydrocele was pulled out completely.If the penicillin test was negative,ok-432 5KE and normal saline 20ml would be injected into the pleural cavity.Four weeks later the effect was evaluated.Results The overall effective rate was 95.8%(46/48),with CR of 81.3%(39/48),PR of 14.6%(7/48),and SD of 4.2%(2/48)without PD.The main toxicity was fever,suffocating and naused.Conclusion Continuous close drain combined with strepococcal preparation(ok-432)is effective method in the treatment of malignant pleural effusion,and its toxicities are slight.