迟发性维生素K缺乏并颅内出血临床分析

Clinical analysis on delayed vitamin K deficiency combined with cerebral hemorrhage

目的 探讨维生素K缺乏症并颅内出血误诊原因、诊断、手术治疗及其预后。方法 回顾性分析我院自1994年1月至2002年收治的维生素K缺乏症并颅内出血患儿48例。结果 本组48例,临床治愈27例,好转10例,放弃治疗3例,死亡8例;其中18例手术者中,15例治愈,2例好转,1例死亡。结论 迟发性维生素K缺乏并颅内出血,见于新生儿和婴儿,发病突然,部分病例有前驱感染和使用抗生素的病史,易于误诊。CT检查、PT检验和维生素K治疗可有效确诊。对有手术指征者,手术治疗可以提高治愈率,降低死亡率,改善生存质量。

Objective To study vitamin K deficiency combined with cerebral hemorrhage on the reasons of its misdiagnosis, diagnosis, operation treatment and prognosis. Meghods Forty-eight patients with vitamin K deficiency and cerebral hemorrhage admitted by our hospital from January 1994 to 2002 were analyzed retrospectively. Results In the forty-eight cases, twenty-seven cases were well cured, ten became better, three gave up treatment and eight died. In eighteen cases undergoing an operation, fifteen cases were well cured, two improved much and one died. Conclusion Delayed vitamin K deficiency combined with cerebral hemorrhage can be seen in neonates and infants. It has a sudden onset. It is easy to be misdiagnosed for some patients have premonitory infection and history of using antibiotic. CT inspection, PT test and vitamin K treatment may be effective for diagnosis. For the patients with operation indications, operation treatment may raise cure rate, reduce death rate and improve survival quality.