摘要
目的 :评价肝纤方配合拉米夫定治疗慢性乙型肝炎 (慢性乙肝 )的疗效。方法 :采用肝纤方 (制大黄、鳖甲、首乌、赤芍等 )联合拉米夫定治疗慢性乙肝 31例 ,并与单用拉米夫定治疗 37例随机对照观察 1年。结果 :肝纤方配合拉米夫定治疗组总有效率 (完全应答 +部分应答 )达 90 .3% ,与对照组 70 .3%比较有显著性差异(P<0 .0 5 ) ;且无一例乙肝病毒基因型变异 (YMDD)阳性发生 ,而对照组出现阳性 5例 (占 16 .7% ) ;其他客观指标治疗组也略优于对照组。结论 :肝纤方弥补了拉米夫定的不足 ,联合使用具有明显的协同作用。
Objective: To assess the therapeutic effects of Ganxian prescription(肝纤方) combined lamivudine in treating chronic hepatitis B. Methods:Thirtyone patients with chronic hepatitis B in treatment group were treated with Ganxian prescription and lamivudine, while 37 patients in control group were just received lamivudine. The therapeutic duration in both group were one year. Results: The overall effective rate including wholly and partly response was 90.3% in treatment group and 70.3% in control group ( P <0.05). No tyrosinemethionioeaspartateastartate (YMDD) mutants were found in treatment group but 5 in control group(16.7%). The other objective markers in treatment group were superior to those in control group. Conclusion: Ganxian prescription can offset the limitation of lamivudine. The therapeutic effects can be significantly improved by Ganxian prescription combined lamivudine to treat chronic hepatitis B.
出处
《中国中西医结合急救杂志》
CAS
2003年第5期290-292,共3页
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
基金
江苏省卫生厅中医药管理局中西医结合重点科研计划项目 (2 0 0 119)
