术前区域性动脉灌注化疗对进展期胃癌预后的影响

Effect of Preoperative Regional Intra-Arterial Infusion Chemo therapy on the Prognosis of Advanced Gastric Cancer

目的 探讨术前区域性动脉灌注化疗对进展期胃癌预后的影响。方法 对 80例行根治性手术切除的进展期胃癌患者 (其中 3 3例术前行介入化疗 )的临床资料进行分析 ,并应用Cox比例风险模型对可能影响胃癌患者预后的临床病理、治疗措施及分子生物学等 11项指标进行多因素回归分析。结果 术前介入化疗组患者 5年生存率为 59.3 % ,显著高于对照组术后 5年生存率的 47.6% (P<0 .0 5)。Cox多因素回归分析显示 ,术前动脉插管介入化疗为影响进展期胃癌患者术后长期存活的独立预后因素之一。

Objective To evaluate the effect of p reoperative regional intra-arterial infusion chemotherapy on the prognosis of a dvanced gastric cancer. Methods The clinical data of 80 patients who u nderwent curative resection for advanced gastric cancers were summarized.Among t hem,33 patients carried out preoperative regional intra-arterial infusion chemo therapy were as the interventional chemotherapy group,and the remaining 47 patie nts were the control group.Eleven factors including clinical and pathological da ta,treatment procedures and molecular biological makers that contributed to the long-term survival rate were analyzed by Cox multivariate regression analysis.Results The 5-year survival rate of the interv entional group was 59.3%,and the control group 47.6% .There was significant difference between two groups ( P <0.05).Multivariate regression analysis revealed that the p reoperative regional intra-arterial infusion chemotherapy was one of the indepe ndent factors affecting the long-term survival of patients with advanced gastri c cancers.Conclusion The preoperative regional intra-art erial infusion chemotherapy has important value for improving the prognosis of g astric cancer.