新型高分子合成树脂类Comfort-DA义齿黏附剂的生物安全性评价

Biological Assessment of a New Synthetic Macromolecular Resin Class of Comfort Denture Adhesive

评价自行研制的高分子合成树脂类 Comfort- DA义齿黏附剂的生物安全性。使用经口途径短期全身毒性试验、溶血试验、细胞毒性试验、致敏试验和口腔黏膜刺激试验等 5种方法 ,未见任何急性毒性反应。材料的溶血率为 2 .95 % ,有良好的血液相容性 ,无明显的细胞毒性作用 ,无致敏性 ,对口腔黏膜无刺激。所研制的 Com fort- DA义齿黏附剂具有良好的生物安全性。

This articel devotes itself to evaluating the biocompatibility of synthetic macromolecular resin class of Comfort denture adhesive, which was developed by the present authors. Acute toxicity, haemolysis, cytotoxicity, sensitization and oral mucous stimulation were tested with standard method (ISO7406-1997 and YY0268-1995). The results showed that no toxic effect was observed with in vivo tests and no cytotoxic effect was observed with in vitro MTT assay. Haemolysis rate of the material(2.95%) indicated good hemaocompatibility. No local mucous membrane irritation reaction was noted after the relevant tests. The developed Comfort denture adhesive exhibited good biocompatibility.