生物活性短肽RGD在骨组织诱导再生中的研究进展

The Advance of Bioactive Peptide RGD in the Research of Bone Regeneration

临床上对创伤、感染和肿瘤切除后所造成大范围骨缺损的修复至今未得到有效的解决。在基质材料中的生物活性物质能对其周围组织及长入基质材料中的纤维组织发生诱导作用 ,使其向骨组织方向生长 ,从而促进骨缺损区的修复。精氨酸 -甘氨酸 -天冬氨酸序列 (Arg- Gly- Asp,RGD)是细胞膜整合素受体与细胞外配体相结合的识别位点。在一定条件下 ,人工合成的 RGD序列的可溶性小分子多肽能够竞争性地与细胞表面的整合素结合 ,将细胞外信息传入细胞内 ,引起细胞一系列的生理变化。目前 ,国内外研究报道合成的 RGD肽具有诱导成骨细胞的生长 ,抑制破骨细胞之间、破骨细胞与基质之间的黏附 ,具有诱导骨再生的能力。本文仅就 RGD肽在骨组织诱导再生中的应用及其进展作一简要综述。

Clinically, there has been so far no effective way to repair the bone-missing of large extent due to gash, infection and removal of tumor. The solution of this problem can be assisted by the addition of bioactive substances to substrate materials, because the growth of peripheral tissue and the fiber tissue growing in the materials can be induced to the direction of bone-tissue by these biomaterials with bioactive peptides. The peptide Arg-Gly-Asp is the point between the integrin which comes from membrane and the ligand. In certain cases, the artificially synthesized RGD can be competitively combined with the integrin on cell surface, and outer-cell information is transmitted into cells, which will cause a series of physiological changes in cells. Presently, it is reported that the RGD has the ability to induce the growth of osteoblasts, restrain the adhesion between osteoclasts and substrates. This paper reviews and introduces the progress made with the work of RGD-inducing bone regeneration.