大肠杆菌O_(157):H_7感染者血清β_2-MG变化的研究

A study on the serum β_2 - microglubin in diarrhea patients infected by E. coli O_(157) : H

目的:通过检测血清β_2-MG,分析E.coli O_(157):H_7感染的HC、HUS病人肾功能的损伤情况,为该病的诊断和治疗提供科学依据。方法:对E.coli O_(157):H_7感染的25例HC病人用RIA法检测血清β_2-MG,并做追踪观察,对31例HUS病人、36例非E.coli O_(157):H_7感染的腹泻病人以及30例健康人群同时检测血清β_2-MG进行比较,并对HC病人血清β_2-MG与血液的其他指标进行分析。结果:HC病人、HUS病人、其他腹泻病人及健康人群血清中β_2-MG的浓度超过正常值分别为100.0％、100.0％、75.0％和13.3％,平均浓度分别为3.14、11.27、2.75和1.79mg/L。HUS病人及健康人群血清β_2-MG与Cr有明显的直线相关关系,连续观察发现HC病人血清β_2-MG浓度逐渐下降,无一例发展成为HUS病例。结论:通过检测E.coli 0_(157):H_7感染的腹泻病人血清β_2-MG并与其他各组人群进行比较发现,HC病人的肾脏受到一定的损伤但在不断的恢复,HUS病人较为严重。合理治疗HC病例,可以减少HUS病例的发生,通过对E.coli O_(157):H_7感染的疑似病例检测β_2-MG对于观察病情,制定治疗方案都有一定的意义。

Objective: To provide scientific basis for diagnosis and treatment of kidney damaged person, we analyzed the kidney damage in the HC patients and HUS patients caused by E. coli O157 : H7 through testing serum β2 - microglubin (β2 - MG). Method: The serum β2 - MG was tested using radioimmuoassay (RIA) in 25 HC patients,as well as 31 HUS patients, 36 diarrhea patients caused by non-E. coli O157 : H7 and 30 healthy person. The serum β2-MG in HC patients was tested continually and the relationship was analyzed between β2-MG and other indexes. Result: The percentage of the serum β2- MG density over normal value was 100. 0%,100. 0%,75. 0% and 13. 3% in HC patients ,HUS patients,other diarrhea patients and healthy person respectively; the average density were 3. 14mg/1,11. 27mg/L,2. 75mg/L and 1. 79mg/l respectively. The linear correlation was obvious between the serum β2- MG and the Creatinine (Cr) in HUS patients and healthy person. The serum β2- MG density descended gradually in HC patients. No HC patients became HUS patients. Conclusion: The kidneys of HC patients were damaged to a certain extent, but the function was recovered gradually; the kidneys of HUS patients were seriously damaged by testing the serum ft - MG, caused by E. coli O157 : H7 and after comparing the indexes in these groups. The HUS patients could be reduced by reasonable therapy to HC patients. It was valueable to observe the patients' condition and to project the therapy scheme by testing the serum β2-MG in suspect patients caused by E. coli O157 : H7.