三维适形放射治疗直肠癌42例疗效分析

Three-dimension conformal radiation therapy for 42 rectal cancer patients

目的 评价三维适形放射治疗对直肠癌患者局部控制率和生存率的影响。方法42例直肠癌患者均采用三维适形放射治疗,先行大野治疗40Gy,1.8～2.0Gy/次,1次/d;后缩野加量24～27Gy,3.0～4.0Gy/次,隔日1次,累积剂量64～67Gy。结果 1、2、3年生存率分别为83.3％、64.3％、45.2％,1、2、3年局部复发率分别为2.4％、11.9％、23.9％。结论 三维适形放射治疗可能提高直肠癌患者的生存率,改善其生存质量。

Objective To evaluate the effects of 3-dimensional conformal radiation therapy(3DCRT) in form of local control and survival of rectal cancer patients. Methods Forty-two patients with rectal cancer were irradiation by 3DCRT. They first received 40 Gy with larger field, at 1.8-2.0 Gy/f, 1 fraction qd, then followed by a boost of 24-27 Gy with reduced field, at 3.0-4.0 Gy/f, 1 fraction qod, to a total dose of 0,64-67 Gy. Results The 1-,2-,3-year survival rates were 83.3% ,64.3% and 45.2% .The 1-,2-,3-year local recurrence rates were 2.4%,11.9% and 23.9%. Conclusion Three-dimensional conformal radiotherapy is able to prolong the survival and improve the life quality of patients with rectal cancer.