环氧合酶-2对鼻咽癌血管生成及预后的影响

Effect of cyclooxygenase-2 expression on angiogenesis and prognosis in nasopharyngeal carcinoma

目的 研究环氧合酶-2(COX-2)在鼻咽癌中的表达及其对血管生成及预后的影响。方法 选取临床资料完整并随访达5年以上的86例鼻咽癌患者,采用免疫组织化学技术检测活检标本中COX-2、血管内皮生长因子(VEGF)表达和微血管密度(MVD)。结果 COX-2在鼻咽癌组织中阳性表达率为73.3％(63/86),与VEGF表达[69.8％(60/86)]呈显著正相关(r_s=0.438,P<0.01),且与肿瘤分级、原发灶范围、颈淋巴结转移、远地转移及较短生存期亦具相关性。MVD平均数为32.3±12.8。结论 COX-2在鼻咽癌组织中高表达,与肿瘤血管生成密切相关,可作为预测鼻咽癌预后的一种有用指标。

Objective To assess the effect of cyclooxygenase-2 (COX-2) expression on angiogenesis and prognosis in nasopharyngeal carcinoma(NPC) . Methods The expression of COX-2, vascular endothelial growth factor (VEGF) and microvascular density (MVD) were determined with immunohistochemical method in 86 NPC patients accrued over 5 years. Results The COX-2 expression rate-73. 3 % (63/86) was positively related to VEGF expression ( r = 0.438, P < 0.01), with association with the tumor pathological grade, extent of primary lesion, lymph node metastasis, distant metastasis and shorter survival. Conclusions COX-2, being highly expressed and strongly correlated with angiogenesis in nasopharyngeal carcinoma, is apt to be used as a predictor of prognosis, including local recurrence and distant metastasis.