肝癌患者集束电极射频消融治疗前后T淋巴细胞及红细胞免疫功能的研究

Changes of T lymphocytes and red cell immunity in the peripheral blood of the patients with primary hepatocyte carcinoma after raiofrequency ablation treatment

目的 研究肝癌患者接受射频消融治疗前后机体T淋巴细胞及红细胞免疫功能的变化。方法 分析 12 0例肝细胞肝癌患者射频消融治疗前和治疗后 3d ,7d和 14d外周血淋巴细胞亚群(T 3 ,T 4,T 8,T4/T 8)和红细胞C 3b受体花环 (RBC C3bR )及免疫复合物花环 (RBC ICR )形成率。结果 所有肝癌患者在射频消融治疗后 7d和 14d ,T 3细胞 ,T 4细胞 ,T 4/T 8及RBC C 3bR ,RBC ICR形成率均明显高于治疗前 (P <0 .0 5 )。结论 采用射频消融治疗肝癌 ,可以改善患者的细胞免疫状态。

Objective To investigate and evaluate the changes of T lymphocytes and red cell immunity of peripheral blood in patients with primary hepatocyte carcinoma (PHCC) after radiofrequency ablation(RFA) treatment. Methods The pre- and post- RFA(3d,7d,14d) peripheral blood T lymphocyte subsets(T3,T4,T8,T4/T8) and red cell immunity (RBC C3 receptor flower and RBC-immuocomplex formation rate) were investigated in 120 patients with PHCC treated by RFA. Results On 7d, 14d after RFA, T3, T4 lymphocytes and T4/T8 were higher than those on preoperative day significantly(P<0.05), and the red cell immunity elevated significantly on 7d and 14d after RFA than those before RFA treatment(P<0.05). Conclusions RFA is an effective method in improving the immunity of patiants with PHCC.