期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

快速老化SAMP10小鼠脑细胞端粒增龄性变化 被引量：1

Age-related changes in telomere of brain cell in SAMP10
下载PDF
导出
摘要 [目的]研究快速老化SAMP10小鼠脑细胞端粒的增龄性变化。[方法]以快速老化模型小白鼠SAMP10为脑老化动物模型 ,采用Southern杂交方法 ,测定了不同月龄SAMR1和SAMP10小鼠脑细胞端粒的变化情况。[结果]SAM的细胞端粒长度在17～25kb之间 ,SAMP10小鼠脑细胞端粒具有随增龄而减少的趋势。[结论]从SAMR1和SAMP10小鼠脑细胞端粒的变化来看 。 To study the age_related changes in telomere of brain cell of mice with brain aging animal. SAMP10 was taken as as brain aging animal model. The Southern hybridization was used to measure the changes in telmere of brain cell in different month_age between SAMR1 and SAMP10. The length of telomere in SAM was 17～25 kb and there was a decreasing trend in brain cell telomere of SAMP 10 while aging. [Conclusion]The contraction of cell telomere has a marked correlation to senile.
作者 王舒 董承超 鲁斌
机构地区 天津中医学院第一附属医院
出处 《天津中医药》 CAS 2003年第5期24-26,共3页 Tianjin Journal of Traditional Chinese Medicine
基金 国家自然科学基金资助项目 (39800197)
关键词 快速老化SAMP10小鼠 脑细胞端粒 增龄性变化 Southern杂交方法 SAMP10 mouse telomere of brain cell aged-related change
分类号 R749.16 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献9

  • 1Harley CB, Futeher AB, Greiter CW. Telomere shorten during ageing of human fibroblasts[J] .Nature, 1990, 345:458.
  • 2Lindsey J, McGill NL Lindsey, LA, et al. In vivo loss of telomere repeats with age in humans[J] . Mutat. Res. 1991,256 : 45.
  • 3Chang E, Harley CB. Telomere Length and replictive aging in human vascular tissue[J] . Proc. Natl. Acad. Sci. USA,1995, 92:11190.
  • 4Allsopp RC, Chang E, Aazam MK, et al. Telomere shortening is associated with call division in vitro and in vivo[J] .Experimental Cell Res. 1995,220:194.
  • 5Allsopp RC, Vaziri H, Patterson, C, et al.Telomere length predicts replicative capacity of human fibroblasts[J] . Proc.Natl. Acad. Sci USA. 1992,89: 10114.
  • 6Harley CB. Telomere loss : mitotic clock or genetic-time bomb[J]. Mutat. Res. 1991,256: 271.
  • 7Rawes V, Kiping D, Kill IR, et al.The Kinetics of senescence in retinal pigmented epithelial cells: a test for the telomere hypothesis of aging? [J] Biochemistry (Moscow) .1997, 62, 1291.
  • 8Vaziri H. Critical telomere shortening regulated by the ataxia telangiectasia gene acts as a DNA damage signal leading to activating of P53 protein and limited Life-span of human diploid fibroblasts[J] . Biochemistry (MOSCOW), 1997, 62:1306.
  • 9Glinicki TV. Telomeres: Influencing the rate of aging[J].Annals New York Academy of Science, 1998, 854: 318.

同被引文献12

  • 1张杰,李溳,崔成德,徐琦.补肾益精方药对老年大鼠染色体端粒DNA重复序列长度的影响[J].中国中医基础医学杂志,2004,10(10):16-17. 被引量：9
  • 2Duong A, Steinmaus C, McHale CM, et al. Reproductive and developmental toxicity of formaldehyde: a systematic review [J]. Mutat Res, 2011,730:118-138.
  • 3Tang X, Bai Y, Duong A,et al. Formaldehyde in China: production, consumption, exposure levels, and health effects [J]. Environ Int, 2009, 35: 1210-1224.
  • 4WHO. Formaldehyde: concise international chemical assessment document 40[R]. Geneva: World Health Organization, 2002.
  • 5Gao NN, Chang Q, Liu DD, et al. Study on genotoxicity of formaldehyde 0n the liver cells in mice [C]. The 3rd International Conference on Bioinformatics and Biomedical Engineering, 2009.
  • 6Murnane JP. Telomere dysfunction and chromosome instability[J]. Mutat Res, 2012, 730: 28-36.
  • 7Skrobot-Vidaeka N, Cukuia A, Ivankovi M,et al. Abrupt telomere shortening in normal hu man fibroblasts[J]. Exp Gerontol, 2010,45:235-242.
  • 8Smith JR, Pereira-Smith OM. Replicative senescence: implications for in vivo aging and tumor suppression[ J]. Science, 1996, 273: 63-67.
  • 9钟天映,陈媛媛,毕利军.端粒与端粒酶的研究——解读2009年诺贝尔生理学或医学奖[J].生物化学与生物物理进展,2009,36(10):1233-1238. 被引量：24
  • 10柯玉洁,秦晓丹,李兰,张玉超,杜娟,丁书茂.甲醛对小鼠骨髓组织的毒性作用[J].中国环境科学,2012,32(6):1129-1133. 被引量：7

引证文献1

二级引证文献1

天津中医药
2003年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部