吗丁啉与必可酮治疗老年哮喘并发胃食管反流的研究

Study of Motihium and beclomethasone dipropionate on senile asthma associated with gastroesophageal reflux

目的 寻找能提高老年性哮喘并发胃食管反流 (GER)治愈率的方法。方法 6 8例患者分为 2组。A组给常规平喘治疗加抗食管反流胃动力药吗丁啉 ,B组仅按常规给平喘药物 ,进行两组疗效对比分析。结果 A组有效率达 94 .1% ,B组有效率达 35 .2 % ,两组比较有显著性差异 (P <0 .0 1)。A组肺功能FEV1,FVC治疗后明显改善 ,治疗前后比较P <0 .0 1。A组与B组的肺功能比较P <0 .0 5。结论 老年性哮喘并发GER的治疗 ,单纯应用平喘药不能达到满意效果 ,只有加用消化道平滑肌促动力作用的抗反流药物 ,才能提高其治愈率。

Objective It is to search the method to enhance the curative rate of patients with senile asthma associated with gastroesophageal reflux (GER). Methods 68 patients with senile asthma associated with GER were divided into two groups. Group A were treated with bronchodilator and anti-esophagus reflux medicine-Motihium while group B were treated with bronchodilator only. Effective rates in two groups were compared. Results The effective rate in group A was 94.1% and that of group B was 35.2%, there was significant difference (P<0.01). The lung function FEV 1, FVC in group A had obviously improved after treatment (P<0.01). The lung function in group A were better than that in group B (P<0.05). Conclusion Concerning treatment of senile asthma associated with gastroesophageal reflux, application of bronchodilator cannot attain satisfactory effect but combined with anti-esophagus reflux medicine such as Motihium.