1999～2002年广州市部分医院口服降糖药使用分析

An Analysis of the Use of Oral Antidiabetic Drugs in Guangzhou in the Years of 1999 to 2002

目的 :了解广州市 38家医院口服降糖药的临床使用情况和变化趋势 ,探讨降糖药的合理选用。方法 :比较 1999～ 2 0 0 2年各种口服降糖药的DDDs以及按 2 0 0 2年的不变价格比较各种口服降糖药的使用金额。结果 :1999～ 2 0 0 2年间 ,口服降糖药用药金额增长 10 1.5 % ,DDDs增长 71.9%。磺酰脲类降糖药的用药金额及用药频度一直保持最高。用药频度一直保持在前三位的依次为二甲双胍、格列吡嗪、格列齐特 ,用药金额在前 4位的分别是格列吡嗪、阿卡波糖、格列齐特、二甲双胍 ;甲苯磺丁脲则无论用药金额还是用药频度基本均是最后 1位。结论 :口服降糖药在糖尿病患者中的服药率大大增多 ,人们用药档次也在提高。临床用药结构比较合理 ,如能增加国产品种 ,降低部分进口品种的价格 ,则能更多的满足糖尿病患者的用药需求。

Objective: To study and evaluate the clinical use of oral anti-diabetic drugs in the hospitals of Guangzhou, and to find out their reasonable use. Methods: The DDDs of many kinds of oral anti-diabetic drugs were compared in the years of 1999 to 2002, and their costs were compared according to the fixed price of 2002. Result: The costs of oral anti-diabetic drugs were increased by 101.5% from 1999 to 2002, while the DDDs was 71.9% . The cost and the use frequency of sulfonylurea were the highest. The three anti-diabetic drugs used most frequently were dimethyldiguanide, glipizide, and gliclazide. The four most expensive dugs were glipizide, acarbose, gliclazide, and dimethyldiguanide. Tolbutamide was used the least, and it cost the least. Conclusion: The use of oral anti-diabetic drugs is increased among the diabetes mellitus patients, and the high-quality drugs are more and more popular. The clinical utilization is comparatively reasonable. If the variety of homemade drugs is increased and the price of drugs such as acarbose is reduced, the demand of more diabetes mellitus patients will be reached.