异位散对子宫内膜异位症家兔的子宫收缩及血管活性物质的影响

The Affections of Yiwei Powder on Uterine Contraction and Vasoactive Substance of the Rabbits with Experimental Endometriosis

目的:探讨中药治疗子宫内膜异位症的作用机理。方法:通过复制子宫内膜异位症的动物模型进行研究。结果:发现经异位散治疗后,模型家兔的子宫收缩频率、幅度、活动力明显降低,由异位内膜所致上升的6-酮前列环素lα(6-keto-PGFlα)、血栓烷素B2(TXB2)水平明显降低。结论:实验揭示了异位散治疗子宫内膜异位症的机理,子宫收缩状况改善与6-keto-PGFlα、TXB2降低有一定的联系。

Objectives:In order to make clear the mechanism that Yiwei Powder treats endometriosis. Methods:The rabbits' experimental endometriosis was made up, treated with Yiwei Powder according to the TCM therapeutic principle quicken the blood and transform stasis, transform phlegm and dissipate binds. Results:Yiwei Powder significantly decreases the concentration of thromboxane B2, 6-keto-prostaglandin Flα, dismiss the hysterospasm which had been elevated by the ectopic endometriotic implants. Conclusion:The change of uterine contraction and vasoactive substance is the mechanism that Yiwei Powder treats endometriosis.