左氧沙星和头孢曲松治疗自发性腹膜炎临床分析

Analysis of the Therapeutic Effect of Levofloxacin and Ceftriaxone in Aged Patients with Spontaneous Bacterial Peritonitis

目的 :评价左氧沙星与头孢曲松治疗自发性腹膜炎的临床疗效和安全性。方法 :6 0例患者随机分为左氧沙星组 (LVLX)2 9例 ,2 0 0mg静脉滴注 ,1日 2次 ;头孢曲松组 (CRO) 31例 ,2g静脉滴注 ,1日 1次 ,疗程均为 7d～ 14d。评价其临床疗效及安全性。结果 :左氧沙星组与头孢曲松组的临床总有效率和不良反应分别为 89 7%、6 9%和 87 1%、6 4 % ,两组差别无显著性 (P >0 0 5 )。结论 :左氧沙星与头孢曲松在治疗自发性腹膜炎上具有相同的疗效及安全性。

OBJECTIVE:To evaluate clinical efficacy and safety of levofloxacin and ceftriaxone in aged patients with spontaneous bacterial peritonitis. METHODS: Sixty aged patients with spontaneous bacterial peritonitis were randomly divided into levofloxacin group (29 cases) and ceftriaxone group (31 cases). Patients of levofloxacin group were treated with levofloxacin, 200 mg iv drip,twice per day; patients of ceftriaxone group treated with ceftriaxone, 2g iv drip,once per day.Duration was 7 to 14 days. RESULTS: The overall efficiency and side effect rate of the two groups were 89 7%,6 9% and 87 1%,6 4% respectively, there was no statistical difference between two groups ( P >0 05). CONCLUSION: Levofloxacin and ceftriaxone have similar curative efficiency and safety in the treatment of aged patients with spontaneous bacterial peritonitis.