线粒体在细胞凋亡中的作用

Effect of Mitochondria on Apoptosis

细胞凋亡属机体的生理机制 ,是多细胞生物更新正常细胞和清除异常细胞的重要手段 ,线粒体为细胞各种生命活动提供能量 ,二者紧密相关 ;线粒体参与细胞凋亡 ,并且是细胞凋亡的调控中心。淋巴细胞 ,巨噬细胞 ,神经细胞 ,肿瘤细胞等的凋亡都证实了这一点 ;NO和 Ca2 +诱导的细胞凋亡也通过线粒体来完成 ;在线粒体调控细胞凋亡机理的研究上也有大量研究成果 ,如 :半胱天冬酶的诱导机制 ,细胞色素 c引起细胞凋亡的机制 ,胞内氧化还原电势改变引起细胞凋亡 ,Bcl-2家族蛋白调控细胞凋亡等。但线粒体参与调控的凋亡机制并不是唯一的细胞凋亡通路。

Apoptosis, which is the basically physiological mechanism,is important on renewing the normal cells and eliminating the abnormal cells for multicytoorganism. Mitochondria, which is one of organelles those have supplied energy for creatures' kinds of activation, takes part in apoptosis and is served as the centre of apoptotic regulation. This has been proved in study of cytokine, macrophage, neurocyte, tumor. Apoptosis inducted by NO and Ca 2+ is also completed through the passage of mitochondria. Many mechanisms, which regulated by Caspase, Cyt c,mitochondrial transmembrane potential, and gene Bcl 2 family etc, have acquired content results. However, the passage that mitochondria has taken part in apoptosis is not the only one and further exploration is needed.Relations of mitochondria and apoptosis in the recent years were discussed