普萘洛尔的合成与拆分研究

Study on Synthesis and Resolution of Propranolol

以1—萘酚、环氧氯丙烷为原料合成得到1-萘基环氧丙基醚,再与异丙胺反应得到外消旋普萘洛尔。外消旋体通过手性拆分试剂L-(+)-酒石酸进行化学拆分,生成的非对映异构体经选择性结晶得到(+)-普萘洛尔-L-(+)-酒石酸盐。

The synthesis and resolution of propranolol were investigated There are two reactions involved in the synthesis of racemic propranolol (1) 1-naphthol reacts with epichlorohydrin to produce 1-naphthyl epihydrinic ether; (2) 1-naphthyl epihydrinic ether reacts with isopropyl amine The chemical resolution of racemic mixture of propranolol was explored using L-(+) -tartaric acid