炎喜康免疫药理作用的实验研究

Experimental Studies on the Immunopharmacological Effects of Isoxicam

炎喜康是一新型非甾体抗炎药,具有明显的抗炎作用。本实验用免疫学方法探讨了该药的抗炎作用的部分机制。结果表明,该药能抑制巨噬细胞吞噬功能,促进抑制性T细胞的抑制作用,这可能是其抑制小鼠迟发型变态反应和大鼠佐剂性关节炎的作用机制之一。该药还能增强SRBC诱导的小鼠脾溶血素的产生和ConA以及LPS诱导的T和B细胞的增殖反应,呈现明显的免疫增强作用。

Isoxicam is a new non-steriod antiinflammatory drug(NSAID), possessing a marked antiinflammatory, antipyretic & analgesic effects It could alternate aspirin, indomethacin & ibuprofen in treating rheumatoid arthritis etc. The immunopharmacological effects of isoxicam were studied by immnuological methods, which purpose is to find out the antiinflammatory mechanism. The results showed thatisoxicam could decrease the phagocytizing function of macrophages & Increase the activation of suppressor T cells, which have some relation to its inhibiting the DTH of mice & the adjuvant-induced arthritis of rats. Isoxicam could increase the hemolysin production of mice & transformation of T & B lymphocytes induced by Con A & LPS, which showed that isoxicam possessed marked immunopotentiating effect.