氟伐他汀治疗高脂血症的临床疗效观察

Clinical observation of effect of flavastatin on the treatment of hyperlipemia

目的:比较氟伐他汀与辛伐他汀对高血脂的疗效。方法:60例高脂血症患者随机分为两组,氟伐他汀组30例,氟伐他汀20mg,1次/d。辛伐他汀组30例,辛伐他汀20mg,1次/d,疗程均为4周。结果:两组患者治疗后TC、TG、LDL-C下降,HDLC升高;组间无差别(P>0.05);两组均无明显不良反应。结论:氟伐他汀与辛伐他汀疗效相似,均为安全,疗效好的降脂药物。

Objective To compare effects of simvastatin and fluvastatin on the treatment of hyperlipemia. Methods Sixty patients with hyperlipemia were randomly divided into two groups, as fluvastatin group and simvastatin group. The former included 30 patients who took 20mg fluvastatin once a day, and the latter included 30 patients who took 20mg simvastatin once a day. Both groups received one therapeutic course of 4 weeks. Results Both groups were decreased TC,TG,LDL-C, and increased HDL-C after treatment . There was no difference between two groups ( P > 0. 05). No side - effect was found. Conclusion Effect of fluvastatin is similar to that of simvastatin. Both are safe and effective for hyperlipemia.