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卵泡刺激素介导睾酮诱导的精子发生抑制的差异 被引量：2

Variability in spermatogenesis suppression induced by testosterone could be mediated by follicle stimulating hormone
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摘要 睾酮 (T)诱导的精子发生抑制是男性激素避孕的理论基础 ,但该方法不能使所有受试者达到无精子 ,部分受试者维持低水平的精子发生。睾内T水平在无精子组与少精子组之间没有差异 ,5α还原酶和双氢睾酮 (DHT)的作用至今未得到证实。大量的实验和部分临床研究表明 ,卵泡刺激素 (FSH)可能是低促性腺激素和低睾内T状态下维持一定水平精子发生的重要因素 ,其机制可能是刺激亮A型精原细胞 (Ap)增加和Ap→B型精原细胞的转化 ,以及介导精子排放。但也有完全不同的研究结果 。
作者 崔毓桂 童建孙 王兴海
机构地区 南京医科大学第一附属医院中心实验室 江苏省计划生育研究所
出处 《生殖医学杂志》 CAS 2003年第5期307-310,共4页 Journal of Reproductive Medicine
关键词 睾酮 精子发生 卵泡刺激素 激素避孕 抑制
分类号 R339.21 [医药卫生—人体生理学] R169.4 [医药卫生—公共卫生与预防医学]
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参考文献17

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  • 2Wallace EM, Gow SM, Wu FCW. Comparison between testosterone enanthate-induced azoospermia and oligospermia in a male contraceptive study. I Plasma luteinizing hormone, follicle stimulating hormone, testosterone, estradiol and inhibin concentrations[J].JCEM, 1993,77(1) :290-293.
  • 3Handel DJ, Wishart S, Conway AJ. Oestradiol enhances testosterone-induced suppression of human spermatogenesis[J]. Hum Reprod, 2000,15 (3) : 672-679.
  • 4Narula A, Gu YQ, O'Donnell L, et al. Variability in sperm suppression during testosterone administration to adult monkeys is related to follicle stimulating hormone suppression and not to intratesticular androgens[J]. JCEM, 2002,87(7):3399-3406.
  • 5Plant TM, Marshall GR. The functional significance of FSH in spermatogenesis and the control of its secretionin male primates[J]. Endocrine Rev, 2001,22(6) :764-786.
  • 6Weinbauer GF, Schlatt S, Walter V, et al. Testosterone-induced inhibition of spermatogenesis is more closely related to suppression of FSH than to tesicular androgen levels in the cynomolgus monkey model (Macaca fascicularis)[J]. J Endocrinol, 2001,168(1) :25-38.
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同被引文献27

  • 1叶涛,徐浩,罗劲祥,陈健,王兵彦,潘东平.不育症患者精浆中睾酮与精子活动率及计数的相关研究[J].广东医学,2004,25(11):1353-1353. 被引量：1
  • 2李座祥,唐文豪,汪朝晖,王琳,王媛媛,马潞林,马旭.中国特发性无精子症和少精子症患者雄激素受体基因CAG重复多态性研究[J].中华男科学杂志,2005,11(5):335-338. 被引量：8
  • 3王国洪,许瑞吉,张中书,王筱劼.少精子症患者血清和精浆性激素水平的测定及其意义[J].标记免疫分析与临床,2005,12(2):82-83. 被引量：6
  • 4杨麦贵,郝晓柯,郑善銮,樊爱琳,屈玲,韦晓明,杨阳,李媛,张竹映.精液FSH、LH、PRL和T水平与精子质量关系的研究[J].中国男科学杂志,2007,21(5):11-14. 被引量：15
  • 5World Health Organization Task Force on Methods for the Regulations of Male Fertility. Rates of testosterone-induced suppression to severe oligozoospermia or azoospermia in two multinational clinical studies[J]. Int J Androl,1995,18(3 ) :157-165.
  • 6Narula A,Gu YQ,O'Donnell L, et al. Variability in storm suppression during testosterone administration to adult monkeys is related to follicle stimulating hormone suppression and not to intratestieular androgens [ J ]. J Clin Endocrinol Metab, 2002, 87 (7) :3399-3406.
  • 7Weinbauer GF, Schlatt S, Walter V, et al. Testosterone-induced inhibition of spermatogenesis is more closely related to suppression of FSH than to testicular androgen levels in the cynomolgus monkey model ( Macaca faseicularis) [ J ]. J Endocrinol, 2001, 168(1 ) :25-38.
  • 8von Eckardstein S, Schmidt A, Kamischke A, et al. CAG repeat length in the androgen receptor gene and gonadotrophin suppression influence the effectiveness of hormonal male contraception [ J ]. Clin Endocrinol (Oxf), 2002, 57 (5) :647-655.
  • 9Sar M, Lubahn DB, French FS, et al. Immunohistochemical localization of the androgen receptor in rat and human tissues [ J ]. Endocrinology, 1990, 127(6):3180-3186.
  • 10Yu B, Handelsman DJ. Pharmacogenetic polymorphisms of the AR and metabolism and susceptibility to hormone-induced azoospermia [J]. J Clin Endocrinol Metab, 2001, 86(9) :4406-4411.

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生殖医学杂志
2003年 第5期

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