阿法骨化醇及二膦酸盐类药物对脊髓损伤患者骨密度的影响

Effects of alfa calcidol and diphosphonates on the BMD of patients with spinal cord injury

目的探讨阿法骨化醇及二膦酸盐类药物对脊髓损伤患者骨密度的影响。方法分别比较 3 1例口服阿法骨化醇与42例未口服该药的脊髓损伤患者 ,以及 2 2例口服二膦酸盐类药物与 2 4例未口服该药的脊髓损伤患者第 4腰椎和股骨近端及其分区骨密度变化的差异。结果是否口服阿法骨化醇对脊髓损伤患者骨密度的保持无显著影响 ;但口服二膦酸盐类药物患者的股骨近端 (total)骨密度较未口服该药物患者下降少 ,两者的差异具有显著性意义 (P <0 .0 5 )。结论口服二膦酸盐类药物对股骨近端的骨密度变化有保护作用。

ObjectiveTo study effects of oral administering alfa calcidol and diphosphonates on the bone mineral density (BMD) of patients with spinal cord injury (SCI).MethodsChanges of BMD of the 4th lumbar spine (L4), the proximal femur (total) and all of its subareas were studied between SCI cases of taking (n=31) and not taking (n=42) alfa calcidol. Changes of BMD between cases of taking diphosphonates (n=22) and not taking (n=24) were also compared.ResultsThere were no significant differences in BMD of L4, the proximal femur and all of its subareas between SCI cases of taking and not taking alfa calcidol. While there was a significant difference in BMD of the proximal femur (total) between cases of taking and not taking diphosphonates ( P<0.05), and the reducing degree of BMD in the former is less than that in the latter.Conclusion Oral administering diphosphonates has a protective effect on SCI patients' BMD of the proximal femur.