溴芬酸钠的合成

Synthesis of Bromfenac Sodium

目的 :对专利合成溴芬酸钠路线进行改进。方法 :以对溴苯甲腈和吲哚啉为原料 ,经酰化、氧化、氯化、酸水解、碱水解开环生成溴芬酸钠。结果 :总收率为 2 8 8%。结论 :工艺适合于生产。

AIM:To develope the synthesis route of bromfenac.METHOD:Bromfenac sodium was prepared from p -bromobenzonitrile and indoline.RESULT:The total yield was 28.8%. CONCLUSION:This synthesis route is applicable for large sale production.